Growing evidence supports the use of high-dose probiotics as intensive support for promoting optimal G.I. and immune function. PROBIOTIC 225 is formulated for extraordinary results. Convenient Stick Packs: No refrigeration Necessary. Take it with you throughout the day! PRObiotic 225 is conveniently dosed in single-serving stick packs and has been scientifically formulated for room-temperature storage, ensuring better patient compliance. PRObiotic 225 mixes well in water or any other cold drink or food for easy use.